4 edition of Ethylene oxide (EtO) found in the catalog.
Ethylene oxide (EtO)
2007 by U.S. Dept. of Labor, Occupational Safety and Health Administration in Washington, D.C .
Written in English
|Contributions||United States. Occupational Safety and Health Administration|
|The Physical Object|
|Number of Pages||28|
Similar to all other petrochemicals, the ethylene oxide industry is cyclical, with the equilibrium between supply and demand driving the state of the industry. Where comparisons over time are possible, exposures appear to have decreased, presumably as control measures have been improved, with the most recent time-weighted average TWA values in the range of 1 ppm or less. Data were not available on exposures that are incurred outside North America and Europe, where almost half of the global amount of ethylene oxide is produced IARC, There is strong evidence that the carcinogenicity of ethylene oxide, a direct-acting alkylating agent, operates by a genotoxic mechanism. Chromosomal aberrations and cancer risk: results of a cohort study from Central Europe. Over the last two decades, EO production has grown at a fast pace in Northeast Asia, owing to capacity developments in China to serve the growing MEG market.
In a follow-up study with prolonged exposure up to 48 weekssignificant increases in LacI mutants were seen in the bone marrow and testes of the ethylene oxide-exposed transgenic mice Recio et al. In addition, the putative ethylene oxide metabolite, glycolaldehyde, has been shown to form DNA—protein crosslinks and DNA single-strand breaks Hengstler et al. There is sufficient evidence in experimental animals for the carcinogenicity of ethylene oxide. No significant trend in mortality was observed in relation to duration of exposure, but the SMR for leukaemia 1. They stressed that for practical purposes, these chemicals should be considered to act similarly to the human carcinogen, vinyl chloride.
Lyon, France: World Health Organization, Exposure to a large variety of chemicals other than ethylene oxide may occur, depending on the types of industrial process and job. The concentration of thioethers excreted in urine collected at the end of sterilization processes was found to be twice as high in non-smoking personnel Vinyl fluoride and vinyl bromide are gases used predominantly for the manufacture of their respective polymers. Signs and Symptoms of Acute Ethylene Oxide Exposure: Signs and symptoms of acute exposure to ethylene oxide may be severe, and include dyspnea shortness of breathcough, pulmonary edema, pneumonia, and respiratory failure. Lympho-haematopoietic malignancies Steenland et al.
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Thioethers in urine of sterilization personnel exposed to ethylene oxide. In a follow-up study of workers in an ethylene oxide-production plant, Tates et al.
A very small proportion 0. The primary hazard associated with EO is its high flammability. The share of EO diverted to non-glycol derivatives can significantly vary by region but has broadly gained momentum where producers were no longer able to compete on the highly commoditized MEG market Western Europe or the United States up until the late s, for instance.
This Alert informs owners, managers, supervisors, engineers, safety professionals, and workers about the explosions, injuries, and deaths that may occur at industrial EtO sterilization facilities and repackaging plants.
Simply follow the link provided above and you can directly download ethylene oxide product stewardship guidance manual chapter and save it to your computer or else you can also read online through our library.
Chemical Formula: Flash Point: Central Supply. Exposures vary with job category: workers involved in loading and distribution of ethylene oxide have the highest exposure.
With regard to product end-users, you could search for an entire product instruction manual and handbook and then download them for free.
Exercise their rights under the law without retaliation, including reporting an injury or raising health and safety concerns with their employer or OSHA.
Curr Drug Metab. Boiling-point: J Toxicol Environ Health. Where comparisons over time are possible, exposures appear to have decreased, presumably as control measures have been improved, with the most recent time-weighted average TWA values in the range of 1 ppm or less.
A model of the ethylene oxide molecule. Epoxide-hydrolase EH activity in the microsomal fraction of human liver averaged 1. It is intended for informational use by persons having technical skill for evaluation under their specific end-use conditions, at their own discretion and risk.
Evaluation There is limited evidence in humans for a causal association of ethylene oxide with lymphatic and haematopoietic cancers specifically lymphoid tumours, i.May 31, · Ethylene Oxide Environmental Protection Agency hazard summary on ethylene oxide that addresses its uses, sources, and methods for assessing personal exposure, as well as information on its hazardous health effects, physical properties, and data on inhalation exposure.
Ethylene oxide (EO) is a basic chemical primarily produced by the catalytic oxidation of ethylene. EO is a chemical intermediate that cannot be directly used and is further reacted to.
Among the alkylene oxides, ethylene oxide, propylene oxide, and butylene oxide are available on large industrial scale. Twenty-five million tons of ethylene oxide and 8 million tons of propylene oxide were produced in (Source: BASF SE), whereas the world annual production of Cited by: made from ethylene in order to produce these end products are polyethylene, ethylene dichloride, ethylene oxide, ethylbenzene, and vinyl acetate, just to name a few.
Global ethylene capacity utilization has remained above 90% since until 's economic meltdown. In2 million tonnes per year (tpy) of ethylene capacity was added. Ethylene oxide may severely irritate or burn mucous membranes and moist skin.
Eye contact may result in conjunctivitis (red, inflamed eyes) and erosion of the cornea. Emergency Life-Support Procedures: Acute exposure to ethylene oxide may require decontamination and life support for the victims.
ethylene treatment, but transcripts show a transient increase at the onset of ripening that is rin depen-dent, suggesting that this gene may be important in regulating ethylene synthesis during the transition from system 1 to system 2 ethylene synthesis (Barry and others ).
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